Research
Research suggests green coffee bean extract (coffea canephora) contains a mixture of chlorogenic acid, polyphenols and 5-caffeylquinic acid. Green coffee beans are coffee beans in their raw, unroasted state which is not achieved in traditionally brewed coffee. Roasting of coffee beans removes a significant portion of the active ingredient chlorogenic acid.1 Hence, Green coffee beans are one of the best natural sources for chlorogenic acid.2 Herbal Magic’s Green Coffee Bean Extract is a jitter free formula that contains less caffeine than a quarter cup of coffee daily (less than 2% caffeine/less than 20 mg daily), and is suitable for those with caffeine sensitivities.
Green Coffee Bean Extract is a 100% all-natural plant concentrate, with standardized bioactives providing 45% chlorogenic acids. Chlorogenic acids have been clinically proven to help induce weight loss.1
The beneficial health effects of chlorogenic acids are well known and have been documented. Various studies have suggested that chlorogenic acids from green coffee beans have been shown to influence postprandial blood sugar concentration, glucose tolerance, serum lipid concentration, and glucose absorption from the intestine. Chlorgenic acid inhibits glucose absorption in the small intestine via inhibition of the activity of glucose-6-phosphatase, limiting the release of glucose into circulation.3,4,5,6
When Green Coffee Bean Extract was studied, the post prandial blood glucose levels of the participants taking GCBE were lower in comparison to control, 133 mg/dL vs. 148 mg/dL respectively (P<0.05).7 In another study comparing GCBE to instant coffee and decaffeinated coffee, results also indicated lower plasma glucose levels with GCBE. consumption. 1 hour post GCBE intake, the mean plasma glucose concentration was 6.23 mmol/l, versus 7.30 mmol/l with decaffeinated coffee intake and 8.25 mmol/l with instant coffee intake. It is thought that Chlorogenic acid might act by inhibiting glucose absorption in the small intestine. Due to the reduced availability of glucose as an energy source, the fat reserves are used for energy instead.1 Therefore, chlorogenic acid can affect adipose metabolism.
Research further shows that GCBE has an effect on glucose and fat metabolism. The clinical benefits of this have been demonstrated in studies: participants lose weight and decrease their fat mass. In a 2012 study, lean mass to fat mass ratio was found to increase in the GCBE group compared to the placebo group: +4.1 +/- 0.7% vs. +1.6 +/- 0.6 respectively (<0.01).1,2 Moreover, clinical trials have revealed a significant difference in body weight in groups taking GCBE when compared with placebo. 1In a clinical trial, participants consuming GCBE saw a reduction in body weight of up to 11 pounds compared to 5 pounds among people consuming the placebo, over a two month period.1
Research has been shown that GCBE can help support heart health and reduce blood pressure.3 When orally administered, chlorogenic acid is metabolized to ferulic acid in the liver and/or kidneys.4 Ferulic acid, which is a metabolite of GCBE containing chlorogenic acid, decreases blood pressure and improves vasoreactivity.5,6 Blood pressure benefits have resulted from amounts as little as 140 mg of chlorogenic acids per day.7
A multicenter, randomized, double-blind, placebo-controlled, parallel group study demonstrated that GCBE can reduce blood pressure in a dose-related manner. After 28 days, 93 mg, and 185 mg of supplementation: 1) significantly reduced systolic blood pressure (SBP) by -4.7±4.5 mmHg, and -5.6±4.2 mmHg respectively, and 2) significantly decreased diastolic blood pressure (DBP) by -3.2±3.2 mmHg, and -3.9±2.8 mmHg respectively, from the baseline, compared to placebo group.8
These effects were further demonstrated when healthy men and women consumed 400 mg of Green Coffee Bean Extract (equivalent to 2 cups of coffee) in a randomized, double-blind, placebo-controlled, crossover trial. Relative to control, the mean post-treatment systolic blood pressure and diastolic blood pressure were significantly lower with chlorogenic acid. These findings further confirm that chlorogenic acid can help lower blood pressure acutely, an effect that, if sustained, would benefit cardiovascular health.9 Moreover, GCBE has antioxidant effects. Fat cells store toxins which are released throughout the body during weight loss, 10,11 resulting in increased circulating concentrations of toxic pollutants. 12,13,14Antioxidants are required to help quench these toxins and reduce damage to surrounding environments.15,16 GCBE provides antioxidants that helps eliminate these toxins, and also help prevent various kinds of diseases associated with oxidative stress, such as cardiovascular disease and some forms of cancer.
Resources
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2 Onakapoya I, Terry R, et al. The use of Green Coffee Extract as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials. Gastroenterology Res Pract. 2011. pii: 382852.
3 Nardon K., Lemaire B. Lafay S. Green coffee extract Svetol can manage weight: a review. AgroFood industry hi-tech. 2007; 18(5:37-39.
4 Blums J, Lemaire B., Lafay Sophie, Effect of a Green Decaffeinated coffee extract on Glycaemia A pilot Prospective Clinical Study. Nutrafoods. 2007; 6(3) 13-17.
5 E Thom., The effect of cholorgenic Acid Enriched Coffee on Glucose Absoption in Healthy Volunteers and Its Effect on Body Mass when used Long-term in Overweight and Obese People. The Journal of International Medical Research. 2007;35:900-908.
6 Henry-Vitrac C, Ibarra A, Roller M, Mérillon JM, Vitrac X. Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. J Agric Food Chem. 2010 Apr 14;58(7):4141-4.
7 Blum J, Lemaire B, Lafay S. Effect of a green decaffeinated coffee extract on glycaemia. NutraFoods Res. 2007;6:13–7.
8 Thom, E. (2007). The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. Journal of International Medical Research, 35(6), 900-908.
9 Dellalibera O, Lemaire B, Lafay S. Svetol® , green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. http://www.realdose.com/wp-content/uploads/2012/01/ Effect_of_Svetol_on_weight_loss_on_humans.pdf. Accessed MAy 21, 2015.
10 Saito I, Tsuchida T, Watanabe T, et al: Effect of coffee bean extract in essential hypertension. Jpn J Med Pharm Sci 2002; 47: 67−74 (in Japanese).
11 Olthof MR, Hollman PC, Michel N, et al: Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J Nutr 2003; 133: 1806−1814.
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13 Ochiai R, Jokura H, Suzuki A, et al: Green coffee bean extract improves human vasoreactivity. Hypertens Res 2004; 27: 731−737.
14 Watanabe, T., Arai, Y., Mitsui, Y., Kusaura, T., Okawa, W., Kajihara, Y., & Saito, I. (2006). The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clinical and experimental hypertension, 28(5), 439-449.
15 Kozuma, K., Tsuchiya, S., Kohori, J., Hase, T., & Tokimitsu, I. (2005). Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertension research, 28(9), 711-718.
16 Mubarak, A., Bondonno, C. P., Liu, A. H., Considine, M. J., Rich, L., Mas, E., ... & Hodgson, J. M. (2012). Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial. Journal of agricultural and food chemistry, 60(36), 9130-9136.
17 Health Canada. Natural Health Products Directorate. Product Monographs. Green Coffee Bean 2014. Available at: www.hc-sc.gc.ca Accessed May 21, 2015.
18 Elobeid MA, Padilla MA, Brock DW, Ruden DM, Allison DB. Endocrine disruptors and obesity: an examination of selected persistent organic pollutants in the NHANES 1999-2002 data. Int J Environ Res Public Health. 2010 July 7(7):2988-3005.
19 Hue O, Marcotte J, Berrigan F, Simoneau M, Doré J, Marceau P, Marceau S, Tremblay A, Teasdale N. Increased plasma levels of toxic pollutants accompanying weight loss induced by hypocaloric diet or by bariatric surgery. Obes Surg. 2006 September 16(9):1145-54.
20 Charlier C, Desaive C, Plomteux G. Human exposure to endocrine disrupters: consequences of gastroplasty on plasma concentration of toxic pollutants. nt J Obes Relat Metab Disord. 2002 November ;26(11):1465-8.
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21 Lim JS, Son HK, Park SK, Jacobs DR Jr, Lee DH. Int J Obes (Lond). Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants.2011;35(5):744-7.
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23 Uttara B, Singh AV, Zamboni P, Mahajan R. Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options. Current Neuropharmacology. 2009;7(1):65-74.